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Article: Reports on immunology findings from University of Tubingen, Department of Immunology provide new insights.
- Article from:
- Biotech Week
- Article date:
- December 31, 2008
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Data detailed in 'Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA-B44 supertype' have been presented. According to a study from Tubingen, Germany, "Human leukocyte antigens (HLA) have long been grouped into supertypes to facilitate peptide-based immunotherapy. Analysis of several hundreds of peptides presented by all nine antigens of the HLA-B44 supertype (HLA-B*18, B*37, B*40, B*41, B*44, B*45, B*47, B*49 and B*50) revealed unique peptide motifs for each of them."
"Taking all supertype members into consideration only 25 out of 670 natural ligands were found on more than one HLA molecule. Further direct ...