|
|
Article: Research from University of Stuttgart yields new data on enzyme research.
- Article from:
- Biotech Week
- Article date:
- January 7, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
According to recent research published in the journal Proteins - Structure Function and Bioinformatics, "The molecular basis of regioselectivity of cytochrome P450 monooxygenases from Bacillus megaterium (CYPI02A1) with its flexible and widely opened active site is still not well understood. In the present work (-)-alpha-pinene bound complexes with two triple mutants were modeled to elucidate the contribution of the three major factors that mediate selectivity: active site shape, protein flexibility, and chemical reactivity of the substrate."
"For the triple mutant A74G F87V L188Q (GVQ), one stable, productive conformation of the substrate (conformation I) was ...
Related newspaper, magazine, and journal articles:
|