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Article: Taste-aversion conditioning, but not immunosuppression conditioning, occurs under partial water deprivation.(Report)
- Article from:
- The Journal of General Psychology
- Article date:
- January 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 Heldref Publications. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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IMMUNOSUPPRESSION CONDITIONING (i.e., the capacity to decrease the magnitude of the antibody response by classical conditioning) was discovered serendipitously by Ader and Cohen (1975). They performed an experiment on taste-aversion conditioning, in which the conditioned stimulus was a 0.1% (wt/ vol) saccharin solution, the unconditioned stimulus was an injection of cyclophosphamide at 50 mg/kg, and the experimental animal was the rat. Because cyclophosphamide is a drug that produces gastrointestinal upset and suppresses the synthesis of antibodies, rats made two associations: (a) saccharin taste with gastrointestinal upset and (b) saccharin taste with loss of immunity. A ...