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Article: The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant.(Research)(Transient receptor potential vanilloid 1)(Clinical report)
- Article from:
- Molecular Pain
- Article date:
- December 4, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Lu Yu [1]; Fei Yang [1]; Hao Luo [1]; Feng-Yu Liu [1]; Ji-Sheng Han [1,2,3]; Guo-Gang Xing (corresponding author) [1,2]; You Wan (corresponding author) [1,2,3]
Background
Transient receptor potential vanilloid 1 (TRPV1) has been shown to be a ligand-gated non-selective cation channel following its successful cloning from rat [1] and human [2, 3] sensory neurons. It can be activated by capsaicin and resiniferatoxin [4], as well as noxious heat [1], low pH [5], some lipid mediators such as anandamide [6] and lipoxygenase product 12-(
S
) hydroxyeicosatetraenoic acid [7]. Results from mutant mice lacking TRPV1 demonstrate that TRPV1 is essential ...
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