|
|
Article: Reports outline medicinal chemistry study results from University of Liege.
- Article from:
- Chemicals & Chemistry
- Article date:
- January 23, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
According to a study from Liege, Belgium, "Taking into account structure-activity relationships obtained with our previous series, new diversely substituted 1,2,4-pyridothiadiazine 1,1-dioxides were designed to obtain novel AMPA potentiators."
"The aim of this work was focused on the improvement of lipophilicity, which is well known as a critical parameter to obtain in vivo active central nervous system agents. For this purpose, two positions on the pyridine ring were privileged to insert selected groups," wrote P. Francotte and colleagues, University of Liege.
The researchers concluded: "Among the synthesized compounds emerged ...