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Article: Research from University of Pittsburgh has provided new data on cholestasis.
- Article from:
- Biotech Week
- Article date:
- January 21, 2009
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"Prior loss-of-function analyses revealed that ATPase class I type 8B member 1 [familial intrahepatic cholestasis 1 (FICI)] posttranslationally activated the farnesoid X receptor (FXR). Mechanisms underlying this regulation were examined by gain-of-function studies in UPS cells, which lack endogenous FICI expression," scientists in the United States report (see also Cholestasis).
"FXR function was assayed in response to wild-type and mutated FICI expression constructs with a human bile salt export pump (BSEP) promoter and a variety of cellular localization techniques. FICI overexpression led to enhanced phosphorylation and nuclear localization of FXR that was ...