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Article: The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.(Research article)(Report)
- Article from:
- Journal of Clinical Investigation
- Article date:
- December 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 American Society for Clinical Investigation. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Defects in programmed cell death (PCD) can promote oncogenesis and resistance to chemotherapy. Apoptosis (type I PCD) has been well studied as a caspase-regulated cellular response to environmental stress and to the activation of oncogenes. Autophagy (type II PCD) is characterized by the accumulation of multi-lamellar vesicles that engulf cytoplasm and organelles, forming autophagosomes marked by microtubule-associated protein light chain 3 (LC3) (1), (2). Autophagosomes then fuse with lysosomes, releasing their contents for hydrolysis. Autodigestion of intracellular proteins and lipids can temporarily sustain energy production by stressed cells, but ...