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Article: Research from University of Colorado has provided new data on antifungals.
- Article from:
- Blood Weekly
- Article date:
- January 29, 2009
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"We utilized a series of analogs of D-V13K (a 26-residue amphipathic alpha-helical antimicrobial peptide, denoted D1) to compare and contrast the role of hydrophobicity on antifungal and antibacterial activity to the results obtained previously with Pseudomonas aeruginosa strains. Antifungal activity for zygomycota fungi decreased with increasing hydrophobicity (D-V13K/A12L/A20L/A23L, denoted D4, the most hydrophobic analog was sixfold less active than D1, the least hydrophobic analog)," scientists in the United States report (see also Antifungals).
"In contrast, antifungal activity for ascomycota fungi increased with increasing hydrophobicity (D4, the most ...