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Article: Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide.(Research article)(Report)
- Article from:
- Breast Cancer Research (Online Edition)
- Article date:
- December 16, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Kannan Krishnamurthy [1]; Guanghu Wang [1]; Dmitriy Rokhfeld [2]; Erhard Bieberich (corresponding author) [1]
Introduction
Breast cancer metastasis is a multi-step process that starts with evasion of cancer cells from the primary tumor, migration through the blood stream and lymphatic ducts, and homing into critical target tissues, creating a life-threatening disease [1]. In all of these steps, cancer cells are exposed to growth factors and chemokines in the serum, vastly enhancing their potential to proliferate and migrate. Most recently, our laboratory has shown that one of these factors is the bile acid sodium deoxycholate (DC) [1]. DC is ...
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