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Article: Use of solubility parameter to design dry suspension of cefaclor as a dual pack system.(Research Paper)
- Article from:
- Indian Journal of Pharmaceutical Sciences
- Article date:
- September 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 Medknow Publications Pvt. Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Byline: Kiran. Kuksal, Kamla. Pathak
One of the important methods to improve the solubility of a less water-soluble drug is by the use of co solvents. The solubility enhancement produced by two binary blends with a common co solvent (water-propylene glycol and propylene glycol-ethyl acetate) was studied against the solubility parameter of solvent blends (a[sub]1 ) to evaluate the solubility parameter of drug (a[sub]2 ). The binary blend water:propylene glycol (20:80) gave maximum solubility with an experimental a[sub]2 value of 16.52 (Cal/cm[sup] 3 )[sup] 0.5 that was comparable to the theoretical value of 16.52 (Cal/cm[sup] 3 )[sup] 0.5 determined by molar ...