Article: Use of solubility parameter to design dry suspension of cefaclor as a dual pack system.(Research Paper)

Byline: Kiran. Kuksal, Kamla. Pathak

One of the important methods to improve the solubility of a less water-soluble drug is by the use of co solvents. The solubility enhancement produced by two binary blends with a common co solvent (water-propylene glycol and propylene glycol-ethyl acetate) was studied against the solubility parameter of solvent blends (a[sub]1 ) to evaluate the solubility parameter of drug (a[sub]2 ). The binary blend water:propylene glycol (20:80) gave maximum solubility with an experimental a[sub]2 value of 16.52 (Cal/cm[sup] 3 )[sup] 0.5 that was comparable to the theoretical value of 16.52 (Cal/cm[sup] 3 )[sup] 0.5 determined by molar ...

Related newspaper, magazine, and journal articles:

 
 
Newsweek Harper's Magazine The Washington Post Chicago Tribune Crain's Chicago Business PRNewswire Pediatric News The Nation Advertising Age The Economist (US) A FREE trial gives you access to over 80 million articles! Access over 6,500 publications with a FREE trial!