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Article: Transcorneal permeation of ciprofloxacin and diclofenac from marketed eye drops.(Short Communication)
- Article from:
- Indian Journal of Pharmaceutical Sciences
- Article date:
- September 1, 2008
- Author:
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Byline: N. Patidar, M. Rathore, D. Sharma, A. Middha, V. Gupta
The purpose of this research was to evaluate the in vitro permeation characteristics of various marketed eye drops of ciprofloxacin (0.3% w/v aqueous solution) and diclofenac (0.1% w/v aqueous solution) through isolated goat cornea. Effect of these drugs on isolated goat eye lenses was also evaluated. Permeation studies were conducted by putting 1 ml of formulation on the cornea fixed between the donor and receptor compartments of an all glass modified Franz diffusion cell and monitoring ciprofloxacin and diclofenac concentration in the receptor (containing normal saline or bicarbonate ringer solution ...