Midtrimester ultrasound for identifying risk of trisomy 21.(Tips from Other Journals)

Although advanced maternal age is the foremost indication for genetic amniocentesis, a significant percentage of women 35 years of age and older decline the procedure. For many women, ultrasonographic evaluation represents an acceptable compromise. Bahado-Singh and associates performed a study to determine the usefulness of ultrasonographic biometry for the detection of Down syndrome and other clinically significant chromosome defects.

Four thousand seventy-nine women 35 years of age or older who underwent amniocentesis were studied. Only pregnancies between 15 and 24 weeks' gestation were included. Standard biometric measurements were taken, including expected values of ...

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