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Article: Researchers from University of Magdeburg describe findings in HIV/AIDS.(Report)
- Article from:
- AIDS Weekly
- Article date:
- February 9, 2009
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"The Nef protein of HIV-1 is a key promoter of disease progression, owing to its dramatic yet ill-defined impact on viral replication. Previously, we have shown that Nef enhances embryonic ectodermal development Tat-mediated transcription in a manner depending on Lck and the cytoplasmic sequestration of the transcriptional repressor embryonic ectodermal development," scientists in Magdeburg, Germany report (see also HIV/AIDS).
"In this study, we report that Lck is activated by Nef and targets protein kinase C theta downstream, leading to the translocation of the kinase Into membrane microdomains. Although microdomain-localized protein kinase C theta is thought to ...
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