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Article: New anesthesia research has been reported by scientists at George Washington University.(Report)
- Article from:
- Biotech Week
- Article date:
- February 11, 2009
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"General anesthesia with propofol and isoflurane induces alterations of the cardiovascular system, including hypotension and changes in heart rate. The preganglionic cardiac vagal neurons (CVNs) are one of the major central components controlling heart rate and autonomic regulation," scientists writing in the journal Anesthesia and Analgesia report (see also Anesthesia).
"In this study, we examined whether propofol and isoflurane act on phasic or tonic gamma-aminobutyric acid type A (GABA(A)) receptor-mediated inhibition in CVNs. CVNs were identified in vitro by retrograde fluorescent labeling. Phasic and tonic GABA Currents in CVNs were examined using the whole ...