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Article: Researchers from Gregor Mendel Institute of Molecular Plant Biology describe findings in life sciences.
- Article from:
- Biotech Week
- Article date:
- February 18, 2009
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Investigators publish new data in the report 'A stepwise pathway for biogenesis of 24-nt secondary siRNAs and spreading of DNA methylation.' According to recent research published in the The EMBO Journal, "We used a transgene system to study spreading of RNA-directed DNA methylation (RdDM) during transcriptional gene silencing in Arabidopsis thaliana. Forward and reverse genetics approaches using this system delineated a stepwise pathway for the biogenesis of secondary siRNAs and unidirectional spreading of methylation from an upstream enhancer element into downstream sequences."
"Trans-acting, hairpin-derived primary siRNAs induce primary RdDM, independently of ...