|
|
Article: New phosphatase study findings have been reported by researchers at University of Ottawa.
- Article from:
- Diabetes Week
- Article date:
- February 16, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
According to recent research published in the Journal of Lipid Research, "Phosphatidate phosphatase-1 (PAP-1) converts phosphatidate to diacylglycerol and plays a key role in the biosynthesis of phospholipids and triacylglycerol (TAG). PAP-1 activity is encoded by members of the lipin family, including lipin-1 (1 alpha and 1 beta), -2, and -3."
"We determined the effect of lipin-1 expression on the assembly and secretion of very low density lipoproteins (VLDL) using McA-RH7777 cells. Expression of lipin-1 alpha or -1 beta increased the synthesis and secretion of [H-3] glycerol-labeled lipids under either basal-or oleate-supplemented conditions. In the presence of ...