Article: Low-dose colchicine effective for acute gout.(RHEUMATOLOY)

SAN FRANCISCO -- Low-dose colchicine appeared to be as effective as a more conventional dose in treating acute gout flares, but produced far fewer side effects in a randomized, double-blind, placebo-controlled trial in 185 patients.

The results support European League Against Rheumatism 2006 consensus guidelines recommending low doses (0.5 mg t.i.d.) when using colchicine to treat gout flare, a recommendation that was made without the backing of clinical trial data, Dr. Robert A. Terkeltaub said at the annual meeting of the American College of Rheumatology.

The study prerandomized 575 patients to receive high-dose colchicine, low-dose colchicine, or ...

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