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Article: New drug delivery research has been reported by scientists at University of London.
- Article from:
- Biotech Week
- Article date:
- February 25, 2009
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"Polysaccharide-based colonic drug delivery requires that the polysaccharide in question avoids pancreatic digestion but undergoes fermentation by the colonic bacteria. Resistance of such dosage forms to pancreatic enzyme digestion is generally only tested in the fasted state, despite the higher enzymatic challenge in the fed state," researchers in London, the United Kingdom report (see also Drug Delivery).
"Theophylline pellets coated with a polysaccharide-based (amylose) colon-specific film were administered to seven healthy volunteers (two-way crossover study, fed/fasted). The transit of the pellets through the gut was followed by gamma scintigraphy. The ...