Article: Alpha-2 adrenergic receptor inhibition of hippocampal CA3 network activity: agonist structure-activity relationships.(COMMUNICATIONS--UNDERGRADUATE)

Alpha-2 adrenergic receptors (ARs) are important regulators of many physiological processes (1). Although many AR ligands have been characterized on peripheral ARs, little is known about their actions in central nervous system. This study is focused on generating functional agonist data for alpha-2 AR which mediates the antiepileptic effects of the endogenous neurotransmitter norepinephrine (NE) in the hippocampus (2). We hypothesized that among the different types of agonists tested, the performance of catecholamines on alpha ARs will be higher than that of the synthetic compounds of the imidazoline and guanidine chemical classes because most of the catecholamines tested ...

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