Article: The intraportal injection model: A practical animal model for hepatic metastases and tumor cell dissemination in human colon cancer.(Research article)(Report)

Authors: Andreas Thalheimer (corresponding author) [1]; Christoph Otto [2]; Marco Bueter [1]; Bertram Illert [1]; Stefan Gattenlohner [3]; Martin Gasser [1]; Detlef Meyer [4]; Martin Fein [1]; Christoph T Germer [1]; Ana M Waaga-Gasser [1]

Background

Colorectal carcinoma constitutes approximately 15% of all cases of cancer and is one of the most common malignant diseases worldwide. Despite multiple advances in its diagnosis and treatment, 20% to 45% of patients with colorectal carcinoma experience local recurrence and/or metastases with a consequent dramatic decline in prognosis. In the industrialized West, therefore, colorectal carcinoma is the ...

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