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Cyclosporine in the treatment of dermatologic disease.(Tips from Other Journals)
- Article from:
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American Family Physician
- Article date:
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May 1, 1997
- Author:
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Copyright informationCOPYRIGHT 1997 American Academy of Family Physicians. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Cyclosporine has been primarily used for the prevention and treatment of organ transplant rejection and graft-versus-host disease. However, recently it has been used in the management of dermatologic disease and has become more popular than other immunosuppressive agents because of weak myelotoxicity, rapid therapeutic action and selectivity for helper T cells. Lim and colleagues review the use of cyclosporine for dermatologic diseases and discuss efficacy, dosage, safety and monitoring.
Cyclosporine interferes with the effective immune response by preventing the generation of antigen-specific population of T cells capable of coordinating an immune response. This function ...
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