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Article: Study results from C. Margadant and colleagues update understanding of cell science.
- Article from:
- Science Letter
- Article date:
- March 3, 2009
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According to recent research from Netherlands, "Re-epithelialization after skin wounding requires both migration and hyperproliferation of keratinocytes. Laminin-332 is deposited during migration over the provisional matrix."
"To investigate the function of the laminin-332 binding integrin alpha 3 beta 1 in wound re-epithelialization, we generated Itga3(flox/flox); K14-Cre mice lacking the alpha 3 subunit specifically in the basal layer of the epidermis. These mice are viable but display several skin defects, including local inflammation, hair loss, basement membrane duplication and microblistering at the dermal-epidermal junction, whereas hemidesmosome assembly ...