|
|
Article: Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?(Research article)(Report)
- Article from:
- BMC Endocrine Disorders
- Article date:
- February 25, 2009
- Author:
CopyrightCOPYRIGHT 2009 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
Authors: Laerke Egefjord [1]; Jens Ledet Jensen [2]; Claus Heiner Bang-Berthelsen [3]; Andreas Br
ønden Petersen [1]; Kamille Smidt [1]; Ole Schmitz [1]; Allan Ertman Karlsen [4]; Flemming Pociot [3]; Fabrice Chimienti [5]; Jørgen Rungby [1]; Nils E Magnusson (corresponding author) [1]
Background
The zinc content of pancreatic [beta]-cells is among the highest in the body [1] and zinc plays an important structural role in many proteins by binding protein molecules in dimers and, in the case of insulin, in oligomers. Insulin is stored as hexameric complexes chelating two zinc ions within vesicles in a crystalline state [2]. ...
Related newspaper, magazine, and journal articles:
|
|
Article: Glucokinase and IRS-2 are required for compensatory [beta] ...
Journal of Clinical Investigation;
January 1, 2007 ;
700+ words
... ... sufficient increase in [beta] cell mass, and overexpression of Irs2 in [beta] cells of HF diet-fed Gc ... normoglycemia via [beta] cell compensation (7). Diabetes ... insulin secretion by [beta] cells is insufficient to compensate ...
|
|