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Article: A single immunization with HA DNA vaccine by electroporation induces early protection against H5N1 avian influenza virus challenge in mice.(Research article)(hemagglutinin)
- Article from:
- BMC Infectious Diseases
- Article date:
- February 12, 2009
- Author:
CopyrightCOPYRIGHT 2009 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Liyun Zheng [1,2]; Fuyan Wang [3]; Zhongdong Yang [4]; Jianjun Chen [1]; Haiyan Chang [3]; Ze Chen (corresponding author) [1,3,4]
Background
The outbreak of human infections of H5N1 influenza in 1997 in Hong Kong and in 2003-2004 in most Asian countries demonstrated that purely avian viruses could be transmitted to humans and cause severe disease [1]. Prior to the Hong Kong outbreak, H5 influenza viruses had been isolated only from avian species [2]. They exist in a non-pathogenic form in wild aquatic birds in different regions of the world and in domestic ducks in Southern China [2, 3, 4]. Highly pathogenic avian influenza (HPAI) H5N1 ...
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