|
|
Article: Studies in the area of Addison disease immunology reported from Newcastle University, Institute of Human Genetics.
- Article from:
- Biotech Week
- Article date:
- March 11, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
Investigators publish new data in the report 'The tryptophan 620 allele of the lymphoid tyrosine phosphatase (PTPN22) gene predisposes to autoimmune Addison's disease.' "Previous studies of the association between autoimmune Addison's disease (AAD) and a nonsynonymous single nucleotide polymorphism (SNP) in the PTPN22 gene (C1858T, pR620W; SNP ID no. rs2476601) have shown conflicting results. We aimed to examine this association using additional cohorts of AAD subjects from the UK and Poland," investigators in the United Kingdom report (see also Addison Disease Immunology).
"DNA samples were obtained from UK and Polish AAD subjects (n=251 and 87, respectively) ...