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Article: Researchers from University of Florence report on findings in enzyme research.
- Article from:
- Biotech Week
- Article date:
- March 18, 2009
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"Thiazide diuretics inhibit all mammalian isoforms of carbonic anhydrase (CA, EC 4.2. 1.1) with a different profile as compared to classical inhibitors. Acting as moderate-weak inhibitors of CA II and CA I, chlorthalidone and indapamide considerably inhibit other isozymes among the 16 CAs present in vertebrates," scientists in Florence, Italy report (see also Enzyme Research).
"These compounds show a different behavior against CAs I and II, with chlorthalidone being 18.3 times more potent against CA II and 150 times more potent against CA I, as compared to indapamide. In the X-ray crystal structures of the CA II-chlorthalidone adduct three active site water ...
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