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Article: Reports from H. Shirasaki and co-researchers add new data to research in allergies.
- Article from:
- Respiratory Therapeutics Week
- Article date:
- March 23, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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"Prostaglandin D-2 (PGD(2)) has been thought to be a potent mediator involved in allergic rhinitis because PGD(2) has been recovered from the nasal lavage fluid of patients with allergic rhinitis after allergen provocation and because PGD(2) receptor antagonists relieved nasal allergic symptoms in an animal model of allergic rhinitis. The inflammatory effects of PGD(2) are exerted through high-affinity interactions with 2 G protein-coupled receptors: D-prostanoid receptor I and chemoattractant-homologous receptor expressed on T(H)2 cells (CRTH2)," scientists in Sapporo, Japan report (see also Allergies).
"CRTH2 may mediate the recruitment of leukocytes during a ...
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