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Article: Data on cancer detailed by researchers at Stanford University.
- Article from:
- Cancer Weekly
- Article date:
- March 31, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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According to recent research from the United States, "Calcitriol actions are mediated by the vitamin D receptor (VDR), a nuclear transcription factor of the steroid-retinoid-thyroid nuclear receptor gene superfamily. Calcitriol inhibits the growth of many cells including cancer cells by inducing cell cycle arrest."
"In some cancer cell lines, calcitriol also induces apoptosis. In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished [H-3] 1,25-dihydroxy vitamin D-3 binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis. A potential caspase-3 ...
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Article: Caspase-2 involved in selective neuronal cell death in HD ...
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June 16, 2004 ;
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... ... NewsRx.com & NewsRx.net) -- Caspase-2 is involved in selective neuronal ... reported E. Hermel, "it is not known which caspase(s) cleaves Htt in vivo or whether regional ... finding that Htt is cleaved in vivo at the caspase consensus site 552." Hermel continued ...
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