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Article: Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis.(Report)
- Article from:
- Canadian Journal of Microbiology
- Article date:
- February 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 NRC Research Press. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Dengue virus (DV) is an enveloped, single-stranded RNA virus belonging to the family Flaviviridae. DV infection causes a wide range of symptoms from an unapparent or mild disease (dengue fever, DF) to severe, life-threatening complications (dengue hemorrhagic fever /dengue shock syndrome, DHF/DSS). The clinical symptoms of DHF/DSS include plasma leakage, hemorrhagic abnormalities, and thrombocytopenia. However, the pathogenic mechanism of DHF/DSS is not clear.
The entry event is often a major determinant of virus host and tissue tropism. Establishment of infection requires entry of DV into host cells, followed by retrograde transport of the ...