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Article: Development and validation of a reversed-phase high-performance liquid chromatographic method for the simultaneous determination of amiloride hydrochloride, atenolol, hydrochlorothiazide, and chlorthalidone in their combined mixtures.(DRUG FORMULATIONS AND CLINICAL METHODS)(Report)
- Article from:
- Journal of AOAC International
- Article date:
- March 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 AOAC International. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The resolution ofmulticomponent preparations is often a complex analytical problem because combined substances may have different chemical structures but similar properties, like chromatographic behavior and UV spectra. Drugs currently used in antihypertensive therapy, such as amiloride hydrochloride (AMH), atenolol (ATE), hydrochlorothiazide (HYD), and chlorthalidone (CHL) constitute an example of this situation, presenting overlapping UV spectra. ATE is a [[beta].sub.1]-selective adrenergic blocking agent, which is used concurrently with diuretics because of their additive effects; it reduces heart rate and the force of the heart muscle contraction and lowers blood ...
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