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Article: A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death.(Report)
- Article from:
- Biochemistry and Cell Biology
- Article date:
- April 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 NRC Research Press. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Antitumor ether lipids (AELs) are lipids with anticancer properties that are characterized by the presence of ether bonds at the sn-1 and sn-2 positions of the glycerol backbone (Lohmeyer and Bittman 1994). The presence of 2 ether bonds in the molecules makes them resistant to metabolism and gives them a long half-life. AELs have the potential to deliver antitumor activity without any mutagenicity because, unlike many other anticancer agents, they do not interact directly with DNA. Alkyllysophospholipids (ALPs) are analogs of lysophosphatidylcholine and are typified by 1-O-octadecyl-2-O-methyl-glycerophosphocholine (ET-18-[OCH.sub.3], Structure 1), ...
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