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Article: Placental tissue mRNA expression of angiogenic factors (AF) and their receptors (AFR) in response to in vitro hypoxia as influenced by maternal nutrition in adolescent sheep at day 75 of pregnancy.(COMMUNICATIONS--UNDERGRADUATE)(Report)
- Article from:
- Proceedings of the North Dakota Academy of Science
- Article date:
- April 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 North Dakota Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Placental and fetal growth is severely compromised in adolescent ewes over nourished throughout gestation. Switching ewes from a high (H) to a moderate-control (C) intake at day 50 of gestation (length of pregnancy in sheep is ~145 days) prevents these negative pregnancy outcomes (1). However, recent analyses suggest that placental proliferation rate and vascularity are perturbed in high intake pregnancies as early as day 50. The aim of this study was to determine incubated placental explant AF/AFR mRNA response to hypoxia in C and H ewes at day 75, and in ewes switched from a H to a C intake (H-C) from day 50 until day 75.
Singleton pregnancies (single sire) ...