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Article: Data on cardiopulmonary bypass discussed by researchers at University of British Columbia.
- Article from:
- Biotech Week
- Article date:
- May 6, 2009
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" Interleukin (IL)-18 is a key modulator of the cytokine response that leads to organ dysfunction and prolonged intensive care unit (ICU) stay after cardiopulmonary bypass surgery. We hypothesised that variation in the pro-inflammatory gene IL-18 is associated with adverse clinical outcome because of a more intense inflammatory response," investigators in Vancouver, Canada report (see also Cardiopulmonary Bypass).
" Haplotypes of the IL-18 gene were inferred from genotypes of 23 Coriell Registry subjects. Four haplotype tag single nucleotide polymorphisms (-607 C/A, -137 G/C, 8148 C/T and 9545 T/G) identified four major haplotype clades. These polymorphisms were ...
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