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Article: Reports by S. Ujino and co-researchers describe recent advances in hepatitis C virus.(Report)
- Article from:
- Hepatitis Weekly
- Article date:
- May 4, 2009
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"The hepatitis C virus (HCV) is a major cause of chronic liver disease. Here, we report a new and effective strategy for inhibiting HCV replication using 17-allylaminogeldanamycin (17-AAG), an inhibitor of heat-shock protein 90 (Hsp90)," investigators in Narashino, Japan report (see also Hepatitis C Virus).
"Hsp90 is a molecular chaperone with a key role in stabilizing the conformation of many oncogenic signaling proteins. We examined the inhibitory effects of 17-AAG on HCV replication in an HCV replicon cell culture system. In HCV replicon cells treated with 17-AAG, we found that HCV RNA replication was suppressed in a dose-dependent manner, and interestingly, ...