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Article: The role of heparan sulfate on adhesion of 47 and 51 kDa outer membrane proteins of Helicobacter pylori to gastric cancer cells.(Report)
- Article from:
- Canadian Journal of Microbiology
- Article date:
- April 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 NRC Research Press. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Helicobacter pylori is a common bacterial pathogen that colonizes the gastric mucosa in humans. It is the most common causative agent of chronic gastritis and other severe gastroduodenal diseases, such as peptic and gastric ulcers, gastric cancer, and mucosa-associated lymphoid tissue lymphoma (Basso and Plebani 2004; Kusters et al. 2006). Studies of H. pylori virulence factors have focused on urease, vacuolating cytotoxin, and cytotoxin-associated antigens. It appears that adhesion of H. pylori to the mucosa is directly associated with mucosal damage (Guruge et al. 1998; Hessey et al. 1990). Adhesion of H. pylori is mediated in part by specific ...