Article: The effect of using a powered toothbrush on MCP-1 and RANTES levels in patients with gingivitis.

The purpose of this pilot study was to investigate if a powered toothbrush significantly reduced the concentration of MCP-1 and RANTES over time in a gingivitis group when compared to a manual toothbrush. MCP-1 and RANTES are pro-inflammatory cytokines that are expressed in gingival crevicular fluid of patients with gingival inflammation.

This study looked at the levels of these cytokines as indicators for a reduction in the host inflammatory and immune response.

Twenty gingivitis patients, 18-65 years of age with pocket depths [less than or equal to]6mm and a minimum of 10% bleeding upon probing were enrolled in this IRB approved pilot study. ...

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