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Article: New hyperoxia study findings recently were reported by K. Woyda and co-researchers.
- Article from:
- Biotech Week
- Article date:
- May 20, 2009
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"Bronchopulmonary dysplasia (BPD) Is characterised by impaired alveolarisation, Inflammation and aberrant vascular development. Phosphodiesterase (PDE) inhibitors can Influence cell proliferation, antagonise Inflammation and restore vascular development and homeostasis, suggesting a therapeutic potential In BPD," investigators in Bad Nauheim, Germany report (see also Hyperoxia).
"The aim of the present study was to Investigate PDE expression In the lung of hyperoxia-exposed mice, and to assess the viability of PDE4 as a therapeutic target In BPD. Newborn C57BL/6N mice were exposed to normoxia or 85% oxygen for 28 days. Animal growth and dynamic respiratory ...