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Article: Research on phosphatase detailed by scientists at University of Wisconsin, Department of Nutritional Sciences.
- Article from:
- Proteomics Weekly
- Article date:
- May 18, 2009
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Researchers detail in 'Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae,' new data in phosphatase. "Little is known about how metalloproteins in the secretory pathway obtain their metal ion cofactors. We used the Pho8 alkaline phosphatase of the yeast Saccharomyces cerevisiae to probe this process in vivo," scientists in the United States report (see also Phosphatase).
"We found that both Pho8 activity and protein accumulation are zinc-dependent and decrease in zinc-limited cells. Low Pho8 accumulation was the result of degradation by vacuolar proteases. Surprisingly, the protective ...