Article: Manufacturer/supplier directory.(Directory)

Article: IL-23 induces human osteoclastogenesis via IL-17 in ...
Arthritis Research & Therapy;  September 23, 2007 ;     700+ words ... ... levels of inflammatory cytokines such as TNF-[alpha], IL-6, and IL-1 are elevated in synovial fluids of patients with RA ... patients with RA inhibits bone resorption and destruction. IL-23, which was recently identified as a heterodimeric ...

Article: The IL-23/IL-17 axis in ...
Journal of Clinical Investigation;  May 1, 2006 ;     700+ words ...IL-23 induces the differentiation of naive [CD4.sup.+] T cells into highly pathogenic helper T cells (Th17/[Th.sub.IL-17]) that produce IL-17, IL-17F, IL-6, and TNF-[alpha], but not IFN-[gamma ...

Article: The IL-21 receptor augments Th2 effector function and ...
Journal of Clinical Investigation;  July 1, 2006 ;     700+ words ...The IL-21 receptor (IL-21R) shows significant homology with the IL-4R, and CD[4.sup.+] Th2 cells are an important source of IL-21. Here we examined whether the IL-21R regulates the development of Th2 responses in vivo. To do ...

Article: IL-13R[alpha]2 and IL-10 coordinately suppress ...
Journal of Clinical Investigation;  October 1, 2007 ;     700+ words ... ... infections are a major health concern. IL-10 has been identified as a critical regulator ... controlling Th2 effector function remain unclear. IL-10 also has paradoxical effects on Th2-associated pathology, with IL-10 deficiency resulting in increased Th2 ...

Article: IL-23 is essential for T cell-mediated colitis and ...
Journal of Clinical Investigation;  May 1, 2006 ;     700+ words ... ... early clinical trials as well as in animal models, IL-12 has been implicated as a major mediator of ... to reverse intestinal inflammation. The cytokine IL-23 shares the same p40 subunit with IL-12, and the anti-p40 mAbs used in human and ...

Article: IL-26 targets epithelial cells through IL-20 and ...
Obesity, Fitness & Wellness Week;  October 16, 2004 ;     700+ words ...2004 OCT 16 - (NewsRx.com & NewsRx.net) -- The T-cell lymphokine IL-26 targets epithelial cells through the IL-20 receptor 1 and IL-10 receptor 2 chains. According to published research from an international team of ...

Article: IL-6 involvement in epithelial cancers.(Commentaries)
Journal of Clinical Investigation;  December 1, 2007 ;     700+ words ...IL-6 is a multifunctional cytokine that was originally characterized ... inflammatory responses; however, elevated expression of IL-6 has been detected in multiple epithelial tumors (1). IL-6 binds to a heterodimeric receptor, which contains the ...