Article: A randomized Phase II trial of pemetrexed plus irinotecan (ALIRI) versus leucovorin-modulated 5-FU plus irinotecan (FOLFIRI) in first-line treatment of locally advanced or metastatic colorectal cancer.(Report)

A randomized Phase II trial of pemetrexed plus irinotecan (ALIRI) versus leucovorin-modulated 5-FU plus irinotecan (FOLFIRI) in first-line treatment of locally advanced or metastatic colorectal cancer

Underhill C, Goldstein D, Gorbounova VA et al., Oncology, 2007, 73, 9-20

5-fluorouracil (5-FU) [+ or -] leucovorin (LV) has been the backbone of metastatic colorectal cancer (CRC) treatment. Progression-free survival (PFS) and overall survival (OS) have increased significantly during the past years, with the addition of irinotecan, oxaliplatin, bevacizumab and cetuximab to available treatments.

Pemetrexed is an antifolate/antimetabolite with ...

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