|
|
Article: A randomized Phase II trial of pemetrexed plus irinotecan (ALIRI) versus leucovorin-modulated 5-FU plus irinotecan (FOLFIRI) in first-line treatment of locally advanced or metastatic colorectal cancer.(Report)
- Article from:
- Advances in Gastrointestinal Cancer
- Article date:
- September 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 Mediscript Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
A randomized Phase II trial of pemetrexed plus irinotecan (ALIRI) versus leucovorin-modulated 5-FU plus irinotecan (FOLFIRI) in first-line treatment of locally advanced or metastatic colorectal cancer
Underhill C, Goldstein D, Gorbounova VA et al., Oncology, 2007, 73, 9-20
5-fluorouracil (5-FU) [+ or -] leucovorin (LV) has been the backbone of metastatic colorectal cancer (CRC) treatment. Progression-free survival (PFS) and overall survival (OS) have increased significantly during the past years, with the addition of irinotecan, oxaliplatin, bevacizumab and cetuximab to available treatments.
Pemetrexed is an antifolate/antimetabolite with ...