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Article: Scientists at Cardiff University target Epstein-Barr virus.(Report)
- Article from:
- Virus Weekly
- Article date:
- June 9, 2009
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"B-lymphocytes are essential for the production of antibodies to fight pathogens and are the cells of origin in 95% of human lymphomas. During their activation, and immortalisation by Epstein-Barr virus (EBV) which contributes to human cancers, B-lymphocytes undergo dramatic changes in cell size and protein content," investigators in Wales report (see also Epstein-Barr Virus).
"This study was initiated to compare the proteome of two B-cell lines, from the same individual, that reflect different patterns of activation, one is EBV negative and the other is EBV positive. Using isobaric tags, LC-MALDI TOF-TOF and subcellular fractionation, we quantified 499 proteins ...