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Article: Studies in the area of angiotensins reported from Royal North Shore Hospital.(Report)
- Article from:
- Biotech Week
- Article date:
- June 10, 2009
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"White CN, Figtree GA, Liu CC, Garcia A, Hamilton EJ, Chia KK, Rasmussen HH. Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase," investigators in Australia report (see also Angiotensins).
"Am J Physiol Cell Physiol 296: C693-C700, 2009. First published February 4, 2009; doi:10.1152/ajpcell.00648.2008.-The sarcolemmal Na+-K+ pump, pivotal in cardiac myocyte function, is inhibited by angiotensin II (ANG II). Since ANG II activates NADPH oxidase, we tested the hypothesis that NADPH oxidase mediates the pump inhibition. Exposure to 100 nmol/l ANG II increased superoxide-sensitive fluorescence of isolated rabbit ventricular ...