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Article: Research conducted at Tohoku University has updated our knowledge about laboratory animals.(Report)
- Article from:
- Science Letter
- Article date:
- June 9, 2009
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"Red cedar-derived bedding materials cause changes in cytochrome P450-dependent microsomal enzyme systems in laboratory animals. We examined the effect of essential oil of red cedar (EORC), as well as the effect of bedding from which it had been removed, on the hepatic expression cytochrome P450s in mice," scientists in Sendai, Japan report (see also Laboratory Animals).
"EORC was obtained from liquid extracts of red cedar bedding by a soft-hydrothermal process and was administered orally to mice. Between days 1 and 2 after administration, hepatic P450s were significantly induced as follows: CYP3As, 7.1 x; CYP1As, 1.6 x; CYP2E1, 1.5 x; CYP2Cs, 1.6 x. A housing ...