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Article: Women's health update: St. John's wort and oral contraceptives.
- Article from:
- Townsend Letter
- Article date:
- July 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Over the last five to ten years, a few rare case reports and a short list of published research have brought to light the possibility that St. John's wort may interfere with oral contraceptive (OC) pills. The main issue is that St. John's Wort induces cytochrome P450 (CYP) enzymes, and therefore may alter the pharmacokinetics of the estrogen and/or progestin and result in a reduction of their contraceptive efficacy.
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Two reports have shown breakthrough bleeding and spotting with co-administration of St. John's wort and DCs. (1), (2) Three studies have indicated an adverse interaction between St. John's wort and OCs. St. John's wort ...
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...St. John's wort was more effective than placebo and ... analysis also found that those taking St. John's wort, made from extracts of the medicinal ... and 2000 that found treatment with St. John's wort to be more effective than with placebo ...
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