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Article: Study findings from University of Liege provide new insights into cystic fibrosis.
- Article from:
- Biotech Week
- Article date:
- June 24, 2009
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"The defect in chloride and sodium transport in cystic fibrosis (CF) patients is a consequence of CF transmembrane conductance regulator (CFTR) loss of function and an abnormal interaction between CFTR and the epithelia] sodium channel (ENaC). A few patients were described with CF-like symptoms, a single CFTR mutation, and an ENaC mutation," investigators in Liege, Belgium report (see also Cystic Fibrosis).
"To study African patients with CF-like symptoms and to relate the disease to gene mutations of both CFTR and ENaC genes, we collected clinical data and DNA samples from 60 African patients with a CF phenotype. The CFTR gene was first analyzed in all patients ...