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Article: Data on cardiology reported by researchers at University of South Dakota.
- Article from:
- Cardiovascular Week
- Article date:
- June 22, 2009
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According to a study from the United States, "Mammalian Tolloid-like 1 (Tll-1) is a pleiotropic metalloprotease that is expressed by a small subset of cells within the precardiac mesoderm and is necessary for proper heart development. Following heart tube formation Tll-1 is expressed by the endocardium and regions of myocardium overlying the region of the muscular interventricular septum."
"Mutations in Tll-1 lead to embryonic lethality due to cardiac defects. We demonstrate that the Tll-1 promoter contains Nkx2-5 binding sites and that the Tll-1 promoter is activated by and directly binds Nkx2-5. Tll-1 expression is ablated by a dominant negative Nkx2-5 or by ...