Article: New gene therapy study findings have been published by scientists at Southern Medical University.

"The cytotoxicity of 5-aza-2'-deoxycytidine (DAC) has been linked to demethylation of the INK4a/ARF tumor suppressor gene locus in various cell systems, but the causality of this association remains unproven. To test this assumption, we have examined the effects of DAC in two human cancer cell lines of differing INK4a/ARF promoter methylation status: MDA-MB-468 breast cancer cells in which INK4a/ARF is unmethylated and normally expressed, and DLD-1 colorectal cancer cells in which INK4a/ARF is methylated and repressed," investigators in Guangzhou, People's Republic of China report (see also Gene Therapy).

"In MDA-MB-468 cells, DAC induces cytotoxicity in the ...

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