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Article: Research from S. Tartari and colleagues has provided new data on amyotrophic lateral sclerosis.
- Article from:
- Biotech Week
- Article date:
- July 1, 2009
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"Motor neuron degeneration in amyotrophic lateral sclerosis involves oxidative damage. Glutathione (GSH) is critical as an antioxidant and a redox modulator," scientists writing in the Febs Journal report (see also Amyotrophic Lateral Sclerosis).
"We used a motor neuronal cell line (NSC-34) to investigate whether wild-type and familial amyotrophic lateral sclerosis-linked G93A mutant Cu,Zn superoxide dismutase (wt/G93ASOD1) modified the GSH pool and glutamate cysteine ligase (GCL), the rate-limiting enzyme for GSH synthesis. We studied the effect of various G93ASOD1 levels and exposure times. Mutant Cu,Zn superoxide dismutase induced an adaptive process involving ...