Article: Research by G. Okugawa and colleagues in schizophrenia provides new insights.

"Perospirone is classified as a second-generation antipsychotic agent for the treatment of schizophrenia. Perospirone binds with high affinity to serotonin 5-HT2A receptors and dopamine D2 receptors," investigators in Osaka, Japan report (see also Schizophrenia).

"There are no reports of clinical comparisons of perospirone and risperidone in multicenter studies. To clarify the clinical traits of perospirone in the treatment of schizophrenia, the clinical efficacies and side-effects of perospirone and risperidone were compared in a randomized clinical multicenter trial. Sixty-six schizophrenia patients were enrolled in the trial. The Positive and Negative Syndrome ...

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