|
|
Article: Scientists at University of Pittsburgh discuss research in combinatorial chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- June 19, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
"Forty-four tetracyclic hydroazulenoisoindoles were synthesized via a tandem cyclopropanatiori/Cope rearrangement, followed by a Diels-Alder sequence from easily available five-membered cyclic cross-conjugated trienones. These trienones were obtained from two different routes depending upon whether R-1 and R-2 are alkyl or amino acid derived functional groups, via a rhodium(I)-catalyzed cycloisomerization reaction," investigators in the United States report.
"To increase diversity, four maleimides and two 1,2,4-triazoline-3,5-diones were used as dienophiles in the Diels-Alder step. Several Diels-Alder adducts were further reacted under palladium-catalyzed ...
Related newspaper, magazine, and journal articles:
|
|
Article: Combinatorial chemistry promises better catalysts ...
Chemical Engineering Progress;
October 1, 1998 ;
700+ words
... ... up new drug discoveries using combinatorial chemistry, researchers here and abroad ... possibilities of this technique. Combinatorial chemistry uses a parallel approach to discover ... based and other companies offer combinatorial chemistry systems that can produce a large ...
|
|